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Protein ＆ Cell. 2019, 10 (05) SCICSCD

Dgcr8 deletion in the primitive heart uncovered novel microRNA regulating the balance of cardiac-vascular gene programOA

Xi ChenLin WangRujin HuangHui QiuPeizhe WangDaren WuYonglin ZhuJia MingYangming WangJianbin WangJie Na

jie.na@tsinghua.edu.cn

  Center for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University    Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, Peking University    School of Life Sciences, Tsinghua University  

摘要：Primitive mammalian heart transforms from a single tube to a four-chambered muscular organ during a short developmental window. We found that knocking out global microRNA by deleting Dgcr8 microprocessor in Mesp1 cardiovascular progenitor cells lead to the formation of extremely dilated and enlarged heart due to defective cardiomyocyte（CM） differentiation. Transcriptome analysis revealed unusual upregulation of vascular gene expression in Dgcr8 cKO hearts. Single cell RNA sequencing study furthe... 更多
  • 专辑：

    理工A(数学物理力学天地生)

  • 专题：

    生物学

  • 分类号：

    Q75

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页码：327-353 页数：27 大小：3960K

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